Neural circuitry underlying pain modulation: expectation, hypnosis, placebo

S1364661312X00032_covhighres

Alexander Ploghausemail, Lino Becerra, Cristina Borras, David Borsook
Harvard Medical School, Massachusetts General Hospital, Martinos NMR Center, 149 Thirteenth Street, Charlestown, MA 02129, USA
DOI: http://dx.doi.org/10.1016/S1364-6613(03)00061-5

Abstract:
The ability to predict the likelihood of an aversive event is an important adaptive capacity. Certainty and uncertainty regarding pain cause different adaptive behavior, emotional states, attentional focus, and perceptual changes. Recent functional neuroimaging studies indicate that certain and uncertain expectation are mediated by different neural pathways–the former having been associated with activity in the rostral anterior cingulate cortex and posterior cerebellum, the latter with activation changes in the ventromedial prefrontal cortex, mid-cingulate cortex and hippocampus. Expectation plays an important role not only in its modulation of acute and chronic pain, but also in other disorders which are characterized by certain expectation (specific phobias) or uncertain expectation (generalized anxiety disorder) of aversive events.

The full articles access details can be found at:
http://www.cell.com/trends/cognitive-sciences/abstract/S1364-6613(03)00061-5

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s